Estimation of eflornithine hydrochloride by UV spectroscopy

Eflornithine is not official in any of the pharmacopoeias, the literarture survey did not reveal any analytical method for quantitative estimation of eflornithine. Thus there is a need for the development of newer effective, sensitive, accurate and economical methods of analysis for quantitative estimations of eflornithine as an active pharmaceutical ingredient. The aim of this work was to develop a sensitive and simple spectrophotometric method for the quantification of DFMO is finding new dimensions of clinical importance. To support its investigation an appropriate analytical method (sensitive, selective, reproducible and simple) for quantification of DFMO is essential. Eflornithine (2-fluoromethyl-DL-ornithine; MDL 71782A; DFMO) is a selective, irreversible inhibitor of ornithine decarboxylase enzyme, one of the key enAmit Kumar*, S.P.Venkatesh Prasad, S.Mohan, Aklavya Kumar Singh Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Uttar Pradesh (INDIA) E-mail : [email protected] Received: 4 August, 2009 ; Accepted: 14 August, 2009